In my honest opinion it should be 100% Wilbur and Proteus.
Wilbur
Best use for map, quest, event challange (Epic and Legendary), Titan for survive (I actually use Wilbur on every Titan color, even Blue Titan), and also raid/war but best is bring synergy team, you can read here How to use Wilbur.
Proteus
Best use for boss fight to stop mana, so map, quest, event challange (Epic and Legendary), raid, war, and decent for Titan, so everywhere.