I’d focus on leveling your 4s before your 5s
You can max 2 4s at the cost of 1 5. 4s doing that will give you versatility for both defenses and offenses and get you into the next cup tier as well as help you in all other areas of the game
(5s on 3rd ascension might as well go to level 70 though since ascension tier is already started)
Wu, rigard, boldtusk, grimm, tiburtus, proteus, little john, gadeirus, melendor, Scarlett, colen, triton