What I’ve done is just take a rainbow team that has excellent synergy and will be able to work however the board lays.
Taking out one side so you can ghost is a good strategy I’ve used when the board was there for it. But the benefit of raiding rainbow is that you’re nimble and you can adjust what you’re doing based on the tiles, if I have yellows I charge cviv and get the defense down going on them, purples charge up Alfrike and paralyze them.
It’s good you’re trying new things that’s how you’ll figure out what works best with your roster, but again my advice is rainbow and consider which heros you have that will make each other stronger when used as a unit.