How the defense is being built

I have a question, which heroes would cooperate well in defense and not interfere with each other. What sentence do you have or, for example, beside the tank, two healers, horses, and on the sides of the attacker. Or maybe a tank hero who beat area heroes or maybe lowering the defenses and adding to the attack? How do you put them in terms of their function and skills?
And the second question is whether it makes sense to use talents on heroes 4 * eg Sonia, Wilbur, Coen?. With 5* I have Alberich, Morgana, Kageburado, Misandra, Elkanen

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